Contextualizing Autophagy during Gametogenesis and Preimplantation Embryonic Development
نویسندگان
چکیده
منابع مشابه
EPIGENETIC MECHANISMS UNDERLYING DIFFERENTIATION DURING MAMMALIAN EMBRYONIC DEVELOPMENT Gametogenesis
the DNA double helix, is organized into a complex chromatin structure with the assistance of histone and nonhistone proteins. As such, chromatin is the physiologically relevant form of eukaryotic genomes. While it is largely uncontested that different genetic compositions of individual species underlie their unique physiology and final morphology, chromatin provides an additional layer for dict...
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Autophagy is commonly observed in metazoan organisms during programmed cell death (PCD), but its function in dying cells has been unclear. We studied the role of autophagy in embryonic cavitation, the earliest PCD process in mammalian development. Embryoid bodies (EBs) derived from cells lacking the autophagy genes, atg5 or beclin 1, fail to cavitate. This defect is due to persistence of cell c...
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Parathyroid hormone-like hormone (PTHLH) was first identified as a parathyroid hormone (PTH)-like factor responsible for humoral hypercalcemia in malignancies in the 1980s. Previous studies demonstrated that PTHLH is expressed in multiple tissues and is an important regulator of cellular and organ growth, development, migration, differentiation, and survival. However, there is a lack of data on...
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To develop a resource for the identification and isolation of genes expressed in the early mammalian embryo, large and representative cDNA libraries were constructed from unfertilized eggs, and two-cell, eight-cell, and blastocyst-stage mouse embryos. Using these libraries, we now report the first stages at which the cytokines interleukin (IL)-6, IL-1 beta, and interferon (IFN)-gamma are transc...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2021
ISSN: 1422-0067
DOI: 10.3390/ijms22126313